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Atsushi Sugiyama Selected Research

Sotalol (Sotalol Hydrochloride)

8/2021Corrigendum to: Torsadogenic Action of Cisapride, dl-Sotalol, Bepridil, and Verapamil Analyzed by the Chronic Atrioventricular Block Cynomolgus Monkeys: Comparison With That Reported in the CiPA In Silico Mechanistic Model.
1/2021Torsadogenic Action of Cisapride, dl-Sotalol, Bepridil, and Verapamil Analyzed by the Chronic Atrioventricular Block Cynomolgus Monkeys: Comparison With That Reported in the CiPA In Silico Mechanistic Model.
9/2019Pharmacological β-adrenoceptor blockade can augment torsadogenic action of IKr inhibitor: Comparison of proarrhythmic effects of d-sotalol and dl-sotalol in the chronic atrioventricular block dogs.
1/2019Measurement of J-Tpeakc along with QT-Interval Prolongation May Increase the Assay Sensitivity and Specificity for Predicting the Onset of Drug-Induced Torsade de Pointes: Experimental Evidences Based on Proarrhythmia Model Animals.
1/2011Microminipig, a Non-rodent Experimental Animal Optimized for Life Science Research: In Vivo Proarrhythmia Models of Drug-Induced Long QT Syndrome: Development of Chronic Atrioventricular Block Model of Microminipig.
1/2011Microminipig, a non-rodent experimental animal optimized for life science research: in vivo proarrhythmia models of drug-induced long QT syndrome: development of chronic atrioventricular block model of microminipig.
10/2005Halothane sensitizes the guinea-pig heart to pharmacological IKr blockade: comparison with urethane anesthesia.

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Atsushi Sugiyama Research Topics

Disease

35Atrioventricular Block
01/2022 - 08/2002
31Torsades de Pointes (Torsade de Pointes)
04/2022 - 04/2002
22Polypoidal Choroidal Vasculopathy
09/2021 - 09/2014
16Long QT Syndrome
01/2018 - 09/2002
13Macular Degeneration (Age-Related Maculopathy)
04/2021 - 09/2014
11Atrial Fibrillation
08/2022 - 05/2005
9Heart Failure
01/2021 - 12/2002
9Neoplasms (Cancer)
01/2018 - 04/2002
8Cardiac Arrhythmias (Arrythmia)
01/2021 - 01/2004
7Bradycardia
04/2022 - 05/2004
6Hypertension (High Blood Pressure)
04/2022 - 05/2005
6Heart Arrest (Cardiac Arrest)
03/2021 - 07/2002
6Tachycardia (Tachyarrhythmias)
03/2021 - 07/2002
6Infections
12/2011 - 04/2002
5Ventricular Tachycardia
12/2018 - 04/2002
5Stomach Neoplasms (Stomach Cancer)
03/2004 - 04/2002
4Ventricular Fibrillation
06/2022 - 08/2002
4Ischemia
01/2021 - 01/2016
4Gastritis
12/2011 - 02/2003
3Myocardial Ischemia (Ischemic Heart Diseases)
04/2022 - 01/2016
3Hypotension (Low Blood Pressure)
03/2021 - 08/2017
3Cardiovascular Diseases (Cardiovascular Disease)
10/2020 - 02/2010
3Human Influenza (Influenza)
05/2016 - 01/2013
3Premature Cardiac Complexes (Extrasystoles)
01/2011 - 01/2005
3Carcinoma (Carcinomatosis)
04/2003 - 10/2002
2Alzheimer Disease (Alzheimer's Disease)
04/2022 - 01/2021
2Bipolar Disorder (Manic Depressive Psychosis)
03/2021 - 12/2018
2Out-of-Hospital Cardiac Arrest
01/2019 - 09/2016
2Geographic Atrophy
06/2017 - 01/2016
2Coronary Vasospasm (Coronary Artery Vasospasm)
12/2016 - 08/2016
2Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy)
01/2016 - 11/2006
2Neoplasm Metastasis (Metastasis)
01/2006 - 09/2004
2Hypoxia (Hypoxemia)
04/2005 - 08/2004
2Adenocarcinoma
04/2003 - 10/2002
1Coronary Artery Disease (Coronary Atherosclerosis)
04/2022
1Myocardial Infarction
04/2022

Drug/Important Bio-Agent (IBA)

23Pharmaceutical PreparationsIBA
07/2021 - 08/2002
15afliberceptIBA
09/2021 - 07/2016
13Halothane (Fluothane)FDA Link
01/2021 - 08/2002
9Ranibizumab (Lucentis)FDA Link
09/2021 - 01/2015
8Retinaldehyde (Retinal)IBA
04/2021 - 09/2014
7Sotalol (Sotalol Hydrochloride)FDA LinkGeneric
08/2021 - 10/2005
5Oseltamivir (Tamiflu)FDA Link
01/2022 - 01/2013
51-phenyl-3,3-dimethyltriazene (PDT)IBA
09/2021 - 01/2017
5cilnidipineIBA
12/2016 - 10/2004
5Amiodarone (Amiodarona)FDA LinkGeneric
06/2016 - 08/2002
5Messenger RNA (mRNA)IBA
01/2011 - 02/2003
4Bepridil (Vascor)FDA Link
08/2021 - 06/2008
4Terfenadine (Seldane)IBA
04/2020 - 06/2003
4nifekalantIBA
01/2014 - 06/2003
4sparfloxacin (AT 4140)FDA Link
01/2006 - 06/2003
3Cisapride (Propulsid)FDA Link
08/2021 - 06/2003
3Moxifloxacin (Avelox)FDA Link
08/2020 - 02/2004
3Antipsychotic Agents (Antipsychotics)IBA
12/2018 - 01/2017
3Vasodilator Agents (Vasodilators)IBA
08/2017 - 01/2016
3Vasopressins (Vasopressin)IBA
12/2016 - 08/2002
3Isoproterenol (Isoprenaline)FDA LinkGeneric
02/2016 - 07/2002
3Proteins (Proteins, Gene)FDA Link
01/2012 - 02/2003
3sematilideIBA
06/2003 - 04/2002
2AVE 0118IBA
08/2022 - 09/2020
2Donepezil (Aricept)FDA LinkGeneric
04/2022 - 01/2021
23-(2-carboxyindol-3-yl)propionic acidIBA
08/2021 - 01/2021
2Verapamil (Calan)FDA LinkGeneric
08/2021 - 01/2021
2DronedaroneFDA Link
01/2021 - 01/2018
2Tyrosine Kinase InhibitorsIBA
01/2020 - 01/2018
2Fluvoxamine (Luvox)FDA LinkGeneric
10/2019 - 02/2015
2Adrenergic Receptors (Adrenergic Receptor)IBA
09/2019 - 12/2002
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
11/2017 - 01/2017
2candesartanIBA
01/2017 - 02/2007
2Nitroglycerin (Dynamite)FDA LinkGeneric
10/2016 - 08/2002
2Complement Factor H (Factor H)IBA
08/2016 - 09/2014
2ONO-AE1-329IBA
03/2016 - 08/2015
2Cardiotonic Agents (Cardiac Stimulants)IBA
03/2016 - 04/2003
2CytokinesIBA
01/2015 - 04/2005
2pilsicainideIBA
01/2013 - 07/2009
2Ion Channels (Ion Channel)IBA
01/2011 - 06/2008
2salicylhydroxamic acid (SHAM)IBA
11/2008 - 07/2007
2Acetylcholine (Acetylcholine Chloride)FDA Link
06/2007 - 07/2002
2Anti-Arrhythmia AgentsIBA
02/2007 - 01/2004
2Biomarkers (Surrogate Marker)IBA
02/2006 - 10/2004
2Glyceraldehyde-3-Phosphate Dehydrogenases (GAPD)IBA
02/2006 - 04/2005
2Thymidine PhosphorylaseIBA
01/2006 - 11/2002
2Anti-Bacterial Agents (Antibiotics)IBA
05/2005 - 02/2004
2Protein Isoforms (Isoforms)IBA
04/2005 - 08/2004
2Mexiletine (Mexitil)FDA LinkGeneric
01/2004 - 08/2003
2Sulpiride (neogama)IBA
06/2003 - 08/2002
1Cholinesterase Inhibitors (Anticholinesterases)IBA
04/2022
1Memantine (Namenda)FDA Link
04/2022
1N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
04/2022

Therapy/Procedure

11Therapeutics
09/2021 - 05/2002
8Photochemotherapy (Photodynamic Therapy)
09/2021 - 01/2017
5Cardiopulmonary Resuscitation (CPR)
01/2021 - 08/2002
5Retreatment
01/2018 - 01/2017
4Oral Administration
01/2011 - 06/2003
3Injections
09/2021 - 01/2018
3Intravitreal Injections
01/2020 - 10/2017
2Heart Massage
06/2022 - 01/2021
2Anesthesia
08/2020 - 10/2005
2Gastrectomy
01/2006 - 05/2002
2Combination Drug Therapy (Combination Chemotherapy)
08/2002 - 05/2002